USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

USC-OGP 2-DE database  Search by                Maps             Select Remote Interfaces [All Interfaces] SWISS-2DPAGE World-2DPAGE Portal World-2DPAGE Repository Exclude local DBs has only effect if a remote interface is selected

Searching in 'USC-OGP 2-DE database' for entry matching: P38646 USC-OGP 2-DE database:  P38646 P38646 General information about the entry View entry in simple text format Entry name GRP75_HUMAN Primary accession number P38646 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Stress-70 protein, mitochondrial; AltName: Full=75 kDa glucose-regulated protein; Short=GRP-75; AltName: Full=Heat shock 70 kDa protein 9; AltName: Full=Mortalin; Short=MOT; AltName: Full=Peptide-binding protein 74; Short=PBP74; Flags: Precursor;. Gene name Name=HSPA9 Synonyms=GRP75, HSPA9B, mt-HSP70 Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein PLATELET_4-7 {PLATELET 4-7} Homo sapiens (Human)   map experimental info   PLATELET_4-7 MAP LOCATIONS: SPOT OGP-0309: pI=5.34; Mw=72160 UVEAL_MELANOMA_3-10 {UVEAL MELANOMA 3-10} Homo sapiens (Human)   map experimental info   UVEAL_MELANOMA_3-10 MAP LOCATIONS: SPOT OGP-1123: pI=5.50; Mw=80748 Cross-references UniProtKB/Swiss-Prot P38646; GRP75_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name GRP75_HUMAN Primary accession number P38646 Secondary accession number(s) B2RCM1 P30036 P31932 Q1HB43 Q53H23 Q6GU03 Q9BWB7 Q9UC56 Sequence was last modified on  May 27, 2002 (version 2) Annotations were last modified on  March 15, 2017 (version 187) Name and origin of the protein Description RecName: Full=Stress-70 protein, mitochondrial; AltName: Full=75 kDa glucose-regulated protein; Short=GRP-75; AltName: Full=Heat shock 70 kDa protein 9; AltName: Full=Mortalin; Short=MOT; AltName: Full=Peptide-binding protein 74; Short=PBP74; Flags: Precursor; Gene name Name=HSPA9 Synonyms=GRP75, HSPA9B, mt-HSP70 Encoded on Name=HSPA9; Synonyms=GRP75, HSPA9B, mt-HSP70 Keywords 3D-structure; Acetylation; ATP-binding; Chaperone; Complete proteome; Direct protein sequencing; Disease mutation; Dwarfism; Methylation; Mitochondrion; Nucleotide-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Transit peptide. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL L11066; -; NOT_ANNOTATED_CDS; mRNA EMBL L15189; AAA67526.1; -; mRNA EMBL AK315177; BAG37618.1; -; mRNA EMBL AK222758; BAD96478.1; -; mRNA EMBL DQ531046; ABF50973.1; -; Genomic_DNA EMBL CH471062; EAW62129.1; -; Genomic_DNA EMBL BC000478; AAH00478.1; -; mRNA EMBL BC024034; AAH24034.1; -; mRNA CCDS CCDS4208.1; -; . PIR B48127; B48127; . RefSeq NP_004125.3; NM_004134.6; . UniGene Hs.184233; -; . PDB 3N8E; X-ray; 2.80 A; A/B=439-597 PDB 4KBO; X-ray; 2.80 A; A=52-431 PDBsum 3N8E; -; . PDBsum 4KBO; -; . ProteinModelPortal P38646; -; . SMR P38646; -; . BioGrid 109545; 213; . IntAct P38646; 58; . MINT MINT-1143092; -; . STRING 9606.ENSP00000297185; -; . iPTMnet P38646; -; . PhosphoSitePlus P38646; -; . SwissPalm P38646; -; . BioMuta HSPA9; -; . DMDM 21264428; -; . DOSAC-COBS-2DPAGE P38646; -; . OGP P38646; -; . REPRODUCTION-2DPAGE IPI00007765; -; . SWISS-2DPAGE P38646; -; . UCD-2DPAGE P38646; -; . EPD P38646; -; . MaxQB P38646; -; . PaxDb P38646; -; . PeptideAtlas P38646; -; . PRIDE P38646; -; . TopDownProteomics P38646; -; . DNASU 3313; -; . Ensembl ENST00000297185; ENSP00000297185; ENSG00000113013; . GeneID 3313; -; . KEGG hsa:3313; -; . UCSC uc003ldf.4; human; . CTD 3313; -; . DisGeNET 3313; -; . GeneCards HSPA9; -; . HGNC HGNC:5244; HSPA9; . HPA CAB005219; -; . HPA HPA000898; -; . MalaCards HSPA9; -; . MIM 182170; phenotype; . MIM 600548; gene; . MIM 616854; phenotype; . neXtProt NX_P38646; -; . OpenTargets ENSG00000113013; -; . PharmGKB PA162391712; -; . eggNOG KOG0102; Eukaryota; . eggNOG COG0443; LUCA; . GeneTree ENSGT00860000133890; -; . HOVERGEN HBG051845; -; . InParanoid P38646; -; . KO K04043; -; . OMA EKMAPPQ; -; . OrthoDB EOG091G0386; -; . PhylomeDB P38646; -; . TreeFam TF105046; -; . Reactome R-HSA-1268020; Mitochondrial protein import; . Reactome R-HSA-3371453; Regulation of HSF1-mediated heat shock response; . SIGNOR P38646; -; . ChiTaRS HSPA9; human; . EvolutionaryTrace P38646; -; . GeneWiki HSPA9; -; . GenomeRNAi 3313; -; . PRO PR:P38646; -; . Proteomes UP000005640; Chromosome 5; . Bgee ENSG00000113013; -; . ExpressionAtlas P38646; baseline and differential; . Genevisible P38646; HS; . GO GO:0005737; C:cytoplasm; TAS:ProtInc; . GO GO:0070062; C:extracellular exosome; IDA:UniProtKB; . GO GO:0031012; C:extracellular matrix; IDA:BHF-UCL; . GO GO:0005925; C:focal adhesion; IDA:UniProtKB; . GO GO:0042645; C:mitochondrial nucleoid; IDA:BHF-UCL; . GO GO:0005739; C:mitochondrion; TAS:UniProtKB; . GO GO:0043209; C:myelin sheath; IEA:Ensembl; . GO GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell; . GO GO:0005524; F:ATP binding; IEA:UniProtKB-KW; . GO GO:0003723; F:RNA binding; IDA:UniProtKB; . GO GO:0031625; F:ubiquitin protein ligase binding; IPI:ParkinsonsUK-UCL; . GO GO:0051082; F:unfolded protein binding; TAS:UniProtKB; . GO GO:0030218; P:erythrocyte differentiation; IMP:UniProtKB; . GO GO:0043066; P:negative regulation of apoptotic process; TAS:UniProtKB; . GO GO:0045647; P:negative regulation of erythrocyte differentiation; IMP:UniProtKB; . GO GO:1902037; P:negative regulation of hematopoietic stem cell differentiation; IEA:Ensembl; . GO GO:0006611; P:protein export from nucleus; IEA:Ensembl; . GO GO:0006457; P:protein folding; IEA:InterPro; . Gene3D 1.20.1270.10; -; 1; . Gene3D 2.60.34.10; -; 1; . HAMAP MF_00332; DnaK; 1; . InterPro IPR012725; Chaperone_DnaK; . InterPro IPR018181; Heat_shock_70_CS; . InterPro IPR029048; HSP70_C; . InterPro IPR029047; HSP70_peptide-bd; . InterPro IPR013126; Hsp_70_fam; . Pfam PF00012; HSP70; 1; . PRINTS PR00301; HEATSHOCK70; . SUPFAM SSF100920; SSF100920; 1; . TIGRFAMs TIGR02350; prok_dnaK; 1; . PROSITE PS00297; HSP70_1; 1; . PROSITE PS00329; HSP70_2; 1; . PROSITE PS01036; HSP70_3; 1; .

Gateways to other related servers

• The World-2DPAGE Constellation - Entry point to the world-wide 2-DPAGE resources.
• World-2DPAGE Repository - A public repository for gel-based proteomics data linked to protein identification published in the literature.
• World-2DPAGE Portal - A dynamic portal to query simultaneously world-wide gel-based proteomics databases.
• SWISS-2DPAGE - The Geneva Two-dimensional polyacrylamide gel electrophoresis database.
• ExPASy - The resources web server of the Swiss Institute of Bioinformatics

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